Introduction: Self medication is one of the most Common problems in our country that have various side effects for users. Some variables related to Self medication and drug Self consumption that we studied them in this research. Methods: This study was a cross- sectional study that 394 samples collected from staff of Tehran's schools randomly. Data were analyzed with statistical software (SPSS).Results: Mean age of sample was 39 year with standard deviation equal 9,and 54 percent of them was female. Main cause of Self medication in samples was: mild sign or symptoms and no need to visit a physician, They used this drug in past in a same problem, to be prescription same drug by physician, recommendation of relatives to using drug, distrust about physician, there wasn't health center's near the house of samples, to gain confidence about drug safety. Although relatives between demographic variable and Self drug usage studid in this study.Discussion: Self drug usage and Self medication in this study was notable that decrease this problem with promotion of their knowledge.